Public health & disease

HIV virus

New twice-yearly shot to prevent HIV achieves 100% success rate in late-stage trial

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In this double-blind, randomized study of 5,300 cisgender women in South Africa and Uganda, 2,134 got the injection and the others took one of two types of daily PrEP pills. The trial from California-based company Gilead Sciences began on August 2021 and, so far, not a single woman who received the injections has contracted HIV. The participants who received either of the oral PrEP options, Truvada and Descovy, had infection rates of about 2% — consistent with the infection rates of oral PrEP in other clinical trials.

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Mouse

Japanese scientists reverse Alzheimer’s synapse damage in mice

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Scientists from the Okinawa Institute of Science and Technology say they have reversed the signs of Alzheimer’s disease in lab mice by restoring the healthy function of synapses, critical parts of neurons that shoot chemical messages to other neurons. If the treatment successfully survives the gauntlet of clinical studies with human participants, it could potentially lead to a groundbreaking new treatment for humans suffering from the deadly disease.

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Silhouette of cannabis leaf

Maryland Gov. Wes Moore set to issue 175,000 pardons for marijuana convictions

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During a news conference, Moore said the executive order will affect “tens of thousands of Marylanders” convicted of misdemeanors. Some may have had more than one conviction pardoned through the process. Advocates praised the move as a way of removing barriers to housing, employment, or educational opportunities based on convictions for conduct that is no longer illegal.

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Credit cards in front of laptop

United States to ban medical debt from credit reports

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In a sweeping change that could improve millions of Americans’ ability to own a home or buy a car, the Biden administration proposed a rule to ban medical debt from credit reports. The rule, announced by Vice President Kamala Harris and Consumer Financial Protection Bureau Director Rohit Chopra, comes as President Joe Biden beefs up his efforts to persuade Americans his administration is lowering costs, a chief concern for voters in the upcoming election.

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Sick woman, stomach pain and hands on abdomen

U.K. researchers identify and treat major cause of inflammatory bowel disease

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For the first time, a major trigger in inflammatory bowel disease (IBD) and related conditions has been identified, and existing drugs can stamp it out, in what scientists call a “massive step” in successfully treating these debilitating chronic conditions. Researchers at the Francis Crick Institute, in collaboration with University College London (UCL) and Imperial College London (ICL), have uncovered a problem gene enhancer that stimulates action along a specific biological pathway that causes IBD inflammation.

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Tetanus vaccination

Global deaths from tetanus have been reduced massively since 1990s

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Tetanus is a bacterial disease that causes paralysis and can lead to death. Globally, it was estimated to kill more than 250,000 people each year in the early 1990s. Most of these deaths were in children. By 2019, annual deaths had fallen to less than 35,000. The rollout of the combined vaccine against diphtheria, tetanus, and pertussis among children has been crucial in driving this.

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X-ray image of the intestine

New bowel cancer drug is found to be 100% effective

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An immunotherapy drug could spare bowel cancer patients the need for surgery and chemotherapy after results showed it was effective in 100% of cases. Jemperli from British pharmaceutical company GSK showed “unprecedented results”, the firm said, with no evidence of disease in all patients treated. The data showed all 42 patients in a trial led by Memorial Sloan Kettering Cancer Center in the U.S. had a complete response to treatment, with no evidence of tumors on scans.

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Contraceptives

Free contraception initiative helps Finland reduce teenage abortions by 66%

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The number of abortions among women under 20 rose during the 1990s in Finland, leading the Nordic country to make morning-after pills available without prescription from 15 years of age and sexual education compulsory in all schools. As a result, the number of abortions fell 66% to 722 in 2023 from 2,144 in 2000 among all teenagers aged 19 or younger in Finland, while the drop was even steeper at 78% among those under 18 in the same period.

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Holding breast cancer ribbon

New blood test can predict breast cancer return

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An “ultra-sensitive” new blood test developed and tested by Institute of Cancer Research (ICR) London can predict if breast cancer will return years before the disease shows up on scans, researchers say. It picks up traces of a tumor’s DNA before a full relapse and was found to be 100% accurate at predicting which patients would see their cancer return. It is hoped that the test can allow treatment to start earlier and improve survival rates.

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Cancer Cells under microscope

Thousands in the U.K. to trial breakthrough personalized cancer vaccines

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Under the new scheme from the U.K. National Health Service, the first of its kind in the world, patients who meet the eligibility criteria and agree to have a blood test and sample of their cancer tissue analyzed will gain immediate access to clinical trials for the new vaccines that experts say represent a new dawn of treatments for cancer. While research into cancer vaccines is at an early stage, trials have already shown they can be effective at killing off any remaining tumor cells after surgery and dramatically cut the risk of cancer returning.

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